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In the UPS, proteins are selectively marked by ubiquitination, the covalent addition of ubiquitin (Ub) molecules to lysine residues, which signals and targets the protein for proteolytic degradation by the 26S proteasome

There are six coronaviruses that continue to cause disease in humans: SARS-CoV-2, Middle Eastern respiratory syndrome coronavirus [MERS-CoV], and the four seasonal endemic HCoVs (OC43, HKU1, 229E, and NL63)